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	Spektrometria mas FT-ICR	MALDI-TOF
Dziedzina	Spektroskopia	Spektroskopia
Rodzina	Process / pipeline	Process / pipeline
Rok powstania	1974	1988
Twórca	Alan Marshall	Michael Karas
Typ	Mass spectrometry technique	Ionization and mass analysis technique
Źródło pierwotne	Comisarow, M. B., & Marshall, A. G. (1974). Fourier transform ion cyclotron resonance spectroscopy. Chemical Physics Letters, 25(2), 282-283.	Karas, M., & Hillenkamp, F. (1988). Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Analytical Chemistry, 60(20), 2299-2301.
Inne nazwy	FT-ICR-MS, Fourier Transform ICR, ICR mass spectrometry	MALDI mass spectrometry, MALDI-TOF-MS, laser desorption mass spectrometry
Pokrewne	4	3
Podsumowanie	Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry is an advanced analytical technique that combines magnetic confinement of ions with Fourier transform data processing to achieve exceptional mass accuracy and resolution. Developed by Comisarow and Marshall in 1974, FT-ICR-MS enables the determination of exact masses and elemental compositions of complex molecules, making it invaluable for environmental chemistry, metabolomics, petroleum characterization, and structural elucidation of unknowns.	Matrix-Assisted Laser Desorption/Ionization (MALDI) combined with Time-of-Flight (TOF) mass analysis, or MALDI-TOF, is a soft ionization mass spectrometry technique that gently ionizes intact biomolecules and volatile organic compounds, then measures their mass-to-charge ratio by measuring flight time through a field-free drift region. Introduced independently by Karas, Hillenkamp, and Tanaka in 1988, MALDI-TOF revolutionized proteomics, microbiology, and organic analysis by enabling mass determination of proteins and polymers exceeding 100 kDa.