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Analiza bayesowska metabolomiki×Analiza multi-omiczna metabolomiki×
DziedzinaBioinformatykaBioinformatyka
RodzinaProcess / pipelineProcess / pipeline
Rok powstania2005–20102000s–2010s (metabolomics ~2000; multi-omics integration ~2010s)
TwórcaSimon Rogers, Mark Girolami and colleagues (Bayesian NMR metabolomics framework, ~2009); broader Bayesian metabolomics developed through 2000s–2010sPioneered collectively; key early integrative frameworks by Nicholson & Lindon (metabolomics) and Hasin, Seldin & Lusis (multi-omics disease mapping)
TypProbabilistic statistical pipelineIntegrative computational pipeline
Źródło pierwotneRogers, S., Scheltema, R. A., & Girolami, M. A. (2009). Bayesian analysis of metabolomic NMR data. Bioinformatics, 25(14), 1809-1815. link ↗Subramanian, I., Verma, S., Kumar, S., Jere, A., & Anamika, K. (2020). Multi-omics data integration, interpretation, and its application. Bioinformatics and Biology Insights, 14, 1177932219899051. link ↗
Inne nazwyBayesian metabolomics, probabilistic metabolomics, Bayesian metabolite profiling, Bayesian metabolic flux analysismetabolomics multi-omics integration, integrated metabolomics, multi-omics metabolite profiling, metabolome-centric multi-omics
Pokrewne65
PodsumowanieBayesian metabolomics analysis applies probabilistic inference to metabolite abundance data — typically from mass spectrometry or NMR spectroscopy — to identify differentially abundant metabolites, annotate spectral features, and integrate pathway knowledge. By encoding prior biological knowledge into prior distributions and propagating uncertainty throughout the analysis, it yields more calibrated probability statements about metabolic differences than classical frequentist testing alone.Multi-omics metabolomics analysis integrates metabolite profiling data — derived from mass spectrometry or NMR spectroscopy — with genomic, transcriptomic, and/or proteomic datasets to build a system-level view of biological phenotypes. By anchoring integration on the metabolome, which reflects the downstream functional output of gene expression and protein activity, this approach connects upstream molecular variation to observable biochemical states, enabling richer mechanistic insight than any single omics layer alone.
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ScholarGatePorównaj metody: Bayesian Metabolomics Analysis · Multi-omics metabolomics analysis. Pobrano 2026-06-18 z https://scholargate.app/pl/compare