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Enkelblind Fractioneel Factorieel Experiment×Single-blind Randomized Controlled Trial×
VakgebiedExperimenteel ontwerpExperimenteel ontwerp
FamilieProcess / pipelineProcess / pipeline
Jaar van ontstaan1940s–1950s (fractional factorial foundations); blinding conventions formalised through 1960s–1980s1948 (formalized); single-blind variant established in mid-20th century clinical trial methodology
GrondleggerFractional factorial theory: R. L. Plackett & J. P. Burman (1946); single-blinding practice codified in clinical trial methodology (20th century)Bradford Hill and colleagues (MRC streptomycin trial, 1948); blinding conventions codified in CONSORT guidelines
TypeControlled experimental designExperimental design — blinded randomized trial
Oorspronkelijke bronBox, G. E. P., Hunter, J. S., & Hunter, W. G. (2005). Statistics for Experimenters: Design, Innovation, and Discovery (2nd ed.). Wiley-Interscience. ISBN: 978-0471718130Schulz, K. F., Altman, D. G., Moher, D., & CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332. DOI ↗
Aliassensingle-masked fractional factorial, single-blind FFD, partially blinded fractional factorial, single-blind 2^(k-p) designsingle-masked RCT, single-blind RCT, single-blind trial, SB-RCT
Verwant55
SamenvattingA single-blind fractional factorial experiment studies multiple factors simultaneously by testing only a strategically chosen subset — a fraction — of all possible factor-level combinations, while keeping participants unaware of which treatment condition they receive. This design yields substantial information about main effects and selected interactions at a fraction of the cost of a full factorial experiment, with single-blinding reducing participant-side response bias.A single-blind randomized controlled trial (SB-RCT) is a rigorous experimental design in which participants are randomly assigned to treatment or control conditions while remaining unaware of which condition they have received. Investigators, outcome assessors, and data analysts are not blinded. By masking participants, the design eliminates placebo and nocebo response biases on the participant side, while preserving investigator flexibility to administer and monitor the intervention.
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ScholarGateMethoden vergelijken: Single-blind Fractional Factorial Experiment · Single-blind Randomized Controlled Trial. Geraadpleegd op 2026-06-19 via https://scholargate.app/nl/compare