Methoden vergelijken

	Sequentiële Analyse (Groepssequentiële Opzet)	Bayesiaanse poweranalyse (Assurance)
Vakgebied	Statistiek	Statistiek
Familie	Hypothesis test	Hypothesis test
Jaar van ontstaan	1977	1986
Grondlegger	P. C. O'Brien & T. R. Fleming; P. C. Pocock	Spiegelhalter & Freedman (1986); O'Hagan, Stevens & Campbell (2005)
Type	Sequential / adaptive hypothesis test	Bayesian sample size determination
Oorspronkelijke bron	O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556.	O'Hagan, A., Stevens, J.W. & Campbell, M.J. (2005). Assurance in Clinical Trial Design. Pharmaceutical Statistics, 4(3), 187–201.
Aliassen	sequential testing, group sequential design, interim analysis, Sıralı Analiz (Sequential Testing / Group Sequential Design)	assurance, bayesian sample size determination, bayesian assurance, Bayesian Güç Analizi (Assurance / Bayesian Sample Size)
Verwant	5	3
Samenvatting	Sequential analysis is a framework for conducting hypothesis tests with pre-planned interim looks at accumulating data, allowing a study to stop early for efficacy or futility while controlling the overall Type I error rate. The group sequential approach was formalised by Pocock (1977) and O'Brien and Fleming (1979), and remains the standard for confirmatory clinical trials and rigorous A/B experiments.	Bayesian power analysis — also called assurance — is a sample size determination method that replaces the frequentist notion of power with a probability-weighted average over a prior distribution on the effect size. First formalised by Spiegelhalter and Freedman (1986) and further developed by O'Hagan, Stevens and Campbell (2005), it answers the question: given our current uncertainty about the true effect, what sample size gives us a high overall probability of obtaining a statistically significant result?