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Retrospectieve geneste case-control studie×Geneste geval-controleonderzoek×
VakgebiedEpidemiologieEpidemiologie
FamilieProcess / pipelineProcess / pipeline
Jaar van ontstaan1973 (formal description); widely adopted in epidemiology from 1980s onward1973–1977
GrondleggerNested case-control formalized by Mantel (1973); retrospective application via historical cohort recordsNathan Mantel (1973); D. C. Thomas (1977 formalization)
TypeObservational analytic study designHybrid observational study design
Oorspronkelijke bronMantel, N. (1973). Synthetic retrospective studies and related topics. Biometrics, 29(3), 479–486. link ↗Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. link ↗
Aliassenretrospective NCC, nested case-control within retrospective cohort, case-control nested in historical cohort, nested CCRNCC study, nested CC design, case-control within cohort, density sampling case-control
Verwant56
SamenvattingA retrospective nested case-control study is an efficient observational design in which cases and matched controls are sampled from within an already-assembled retrospective cohort. Exposure data are retrieved from historical records only for selected participants, dramatically reducing data-collection costs while retaining most of the analytic power of the full cohort. It is widely used in pharmacoepidemiology, occupational health, and disease-registry research.A nested case-control study is an efficient observational design embedded within a defined cohort. For each participant who develops the outcome of interest (a case), a small number of matched controls are sampled from those still at risk at the same point in time. This density-sampling strategy yields odds ratios that approximate incidence-rate ratios from the full cohort at a fraction of the data-collection cost — making it the preferred alternative when measuring exposures for all cohort members would be prohibitively expensive or technically demanding.
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ScholarGateMethoden vergelijken: Retrospective nested case-control · Nested case-control. Geraadpleegd op 2026-06-15 via https://scholargate.app/nl/compare