Methoden vergelijken
Bekijk de geselecteerde methoden naast elkaar; rijen die verschillen zijn gemarkeerd.
| Pragmatische genestelde case-controlstudie× | Pragmatisch gerandomiseerd klinisch onderzoek× | |
|---|---|---|
| Vakgebied | Epidemiologie | Epidemiologie |
| Familie | Process / pipeline | Process / pipeline |
| Jaar van ontstaan≠ | 1977 (nested case-control); pragmatic variant emerged in real-world evidence research from 1990s onwards | 1967 |
| Grondlegger≠ | Duncan Thomas (nested case-control); pragmatic design concept from Schwartz & Lellouch (1967) | Daniel Schwartz & Joseph Lellouch |
| Type≠ | Observational epidemiological study design | Interventional study design |
| Oorspronkelijke bron≠ | Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. link ↗ | Schwartz, D., & Lellouch, J. (1967). Explanatory and pragmatic attitudes in therapeutical trials. Journal of Chronic Diseases, 20(8), 637–648. DOI ↗ |
| Aliassen | real-world nested case-control, pragmatic NCC, nested case-control in routine data, real-world evidence nested case-control | pragmatic RCT, effectiveness trial, real-world RCT, practical clinical trial |
| Verwant≠ | 5 | 6 |
| Samenvatting≠ | A pragmatic nested case-control study embeds a case-control analysis within a pre-existing real-world cohort — typically drawn from electronic health records, administrative claims, or disease registries — to examine associations between exposures and outcomes under routine clinical conditions. Controls are sampled from the risk set (those still at risk at the time each case occurs), preserving temporal sequence while dramatically reducing data-collection costs compared with a full cohort analysis. | A pragmatic randomized clinical trial (pragmatic RCT) is an interventional study that tests whether a treatment works under routine clinical conditions, as opposed to the tightly controlled setting of an explanatory trial. It prioritizes broad eligibility, flexible delivery, and patient-relevant outcomes to answer the question 'Does this treatment work in everyday practice?' rather than 'Can this treatment work under ideal circumstances?' The distinction between pragmatic and explanatory trials was formally articulated by Schwartz and Lellouch in 1967 and operationalized by the PRECIS tool in 2009. |
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