Methoden vergelijken

	Pragmatisch Volledig Factorieel Experiment	Pragmatisch Factorieel Experiment
Vakgebied	Experimenteel ontwerp	Experimenteel ontwerp
Familie	Process / pipeline	Process / pipeline
Jaar van ontstaan	1920s (factorial); 1967/2009 (pragmatic framework)	2000s–2010s (formal integration)
Grondlegger	Full factorial: R.A. Fisher (1920s); Pragmatic framing: Schwartz & Lellouch (1967), formalized by Thorpe et al. (2009)	Synthesized from pragmatic trial methodology (Schwartz & Lellouch, 1967) and factorial design principles (Fisher, 1935); formalized in clinical research contexts in the 2000s–2010s
Type	Experimental design	Experimental trial design
Oorspronkelijke bron	Thorpe, K. E., Zwarenstein, M., Oxman, A. D., Treweek, S., Furberg, C. D., Altman, D. G., ... & Chalmers, I. (2009). A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. Journal of Clinical Epidemiology, 62(5), 464-475.	Loudon, K., Treweek, S., Sullivan, F., Donnan, P., Thorpe, K. E., & Zwarenstein, M. (2015). The PRECIS-2 tool: designing trials that are fit for purpose. BMJ, 350, h2147.
Aliassen	pragmatic factorial trial, real-world full factorial design, effectiveness full factorial experiment, pragmatic 2^k experiment	pragmatic factorial trial, pragmatic factorial RCT, real-world factorial design, PFE
Verwant	6	3
Samenvatting	A pragmatic full factorial experiment combines the complete crossing of all factor levels (the full factorial structure) with the broad eligibility criteria, flexible delivery, and real-world conditions of a pragmatic trial. Every possible combination of factors is tested simultaneously, yielding both main effects and all interaction effects, while deliberately relaxing strict laboratory controls to reflect how interventions actually operate in practice.	A pragmatic factorial experiment combines two powerful methodological frameworks: the factorial experimental design — which tests multiple intervention components simultaneously — and the pragmatic trial orientation, which prioritizes real-world applicability, broad eligibility criteria, and flexible delivery conditions. The result is a design that efficiently evaluates which components of a complex intervention work, and whether they interact, while maintaining ecological validity for health, behavioral, and educational research.