Methoden vergelijken

	PET Kinetische Modellering	OCT Angiografie
Vakgebied	Medische beeldvorming	Medische beeldvorming
Familie	Process / pipeline	Process / pipeline
Jaar van ontstaan	1983	2012
Grondlegger	Christoph Patlak	Yali Jia
Type	Mathematical framework for tracer kinetics in PET imaging	Optical imaging technique for vasculature visualization
Oorspronkelijke bron	Patlak, C. S., Blasberg, R. G., Fenstermacher, J. D. (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Journal of Cerebral Blood Flow & Metabolism, 3(1), 1-7.	Jia, Y., Tan, O., Tokayer, J., et al. (2012). Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Optics Express, 20(4), 4710-4725.
Aliassen	PET pharmacokinetics, Dynamic PET, PET compartmental modeling	OCTA, OCT-A
Verwant	5	5
Samenvatting	PET kinetic modeling is a quantitative analysis technique that tracks the temporal behavior of radioactive tracers in tissue to extract physiological parameters such as blood flow, metabolic rate, and receptor density. Established by Patlak, Logan, and Gunn in the 1980s and 1990s, kinetic modeling transforms raw PET time-activity curves into interpretable biological measures. It is widely used in neurology, oncology, and cardiology to assess disease severity, treatment response, and regional tissue function.	Optical Coherence Tomography Angiography (OCTA) is a non-invasive imaging technique that visualizes the microvasculature in the retina and choroid by detecting motion contrast from flowing blood. Developed by Jia and colleagues in 2012, OCTA uses repeated OCT scans of the same tissue location to identify blood flow based on the decorrelation signal. It has become a critical diagnostic tool in ophthalmology for detecting retinal and macular diseases without requiring fluorescein injection.