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Multicentrisch Ecologisch Onderzoek×Dosis-responsanalyse×
VakgebiedEpidemiologieEpidemiologie
FamilieProcess / pipelineProcess / pipeline
Jaar van ontstaan1980s–1990s (formal methodological description)Conceptual roots 16th century; modern epidemiological application mid-20th century
GrondleggerEpidemiological tradition; methodologically articulated by Morgenstern (1982) and Susser (1994)Paracelsus (conceptual foundation); formalized by John Snow and later Bradford Hill
TypeObservational epidemiological study designQuantitative analytical method
Oorspronkelijke bronMorgenstern, H. (1982). Uses of ecologic analysis in epidemiologic research. American Journal of Public Health, 72(12), 1336–1344. DOI ↗Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
Aliassenmulti-site ecological study, multinational ecological study, pooled ecological analysis, multicenter aggregate studyexposure-response analysis, concentration-response modeling, dose-response modeling, DRA
Verwant64
SamenvattingA multicenter ecological study is an observational epidemiological design in which the units of analysis are groups — such as cities, regions, or countries — rather than individuals, and data are pooled from two or more distinct centers or geographic areas. The approach links aggregate exposure measures (e.g., average pollution levels, vaccination coverage rates) to aggregate outcome rates (e.g., disease incidence per 100,000) across multiple populations, enabling comparisons that would be infeasible within any single site.Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.
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ScholarGateMethoden vergelijken: Multicenter Ecological Study · Dose-Response Analysis. Geraadpleegd op 2026-06-15 via https://scholargate.app/nl/compare