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Matched Case-Crossover Design×Geneste geval-controleonderzoek×
VakgebiedEpidemiologieEpidemiologie
FamilieProcess / pipelineProcess / pipeline
Jaar van ontstaan1991 (base design); matched variant refined ~1998–20001973–1977
GrondleggerMalcolm Maclure (case-crossover); time-matched variant developed by Navidi (1998) and Lumley & Levy (2000)Nathan Mantel (1973); D. C. Thomas (1977 formalization)
TypeObservational epidemiological designHybrid observational study design
Oorspronkelijke bronMaclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. link ↗
Aliassenmatched case-crossover study, time-matched case-crossover, bidirectional case-crossover, symmetric bidirectional designNCC study, nested CC design, case-control within cohort, density sampling case-control
Verwant36
SamenvattingThe matched case-crossover design is a self-controlled observational study in which each case serves as its own control. A short hazard window immediately before the acute event is compared with one or more matched control windows — selected to have the same day of week, season, or other time-varying covariate — making the design robust to stable individual confounders and calendar-time trends simultaneously.A nested case-control study is an efficient observational design embedded within a defined cohort. For each participant who develops the outcome of interest (a case), a small number of matched controls are sampled from those still at risk at the same point in time. This density-sampling strategy yields odds ratios that approximate incidence-rate ratios from the full cohort at a fraction of the data-collection cost — making it the preferred alternative when measuring exposures for all cohort members would be prohibitively expensive or technically demanding.
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ScholarGateMethoden vergelijken: Matched Case-Crossover Design · Nested case-control. Geraadpleegd op 2026-06-17 via https://scholargate.app/nl/compare