Methoden vergelijken

	Instrumentele Variabelen (IV) Methode voor Causale Inferentie	Markov-ketenmodel in de gezondheidseconomie
Vakgebied	Gezondheidseconomie	Gezondheidseconomie
Familie	Process / pipeline	Process / pipeline
Jaar van ontstaan	1990s (modern applications)	1983
Grondlegger	Angrist & Pischke (applied econometrics); rooted in econometric theory	Beck & Pauker (medical decision analysis, Massachusetts General Hospital)
Type	Method	Method
Oorspronkelijke bron	Angrist, J. D., & Pischke, J. S. (2009). Mostly Harmless Econometrics: An Empiricist's Companion. Princeton: Princeton University Press.	Beck, J. R., & Pauker, S. G. (1983). The Markov Process in Medical Prognosis. Medical Decision Making, 3(4), 419-458.
Aliassen	IV, two-stage least squares, TSLS, causal estimation	Markov model, state transition model, cohort simulation
Verwant	3	5
Samenvatting	Instrumental variables (IV) is an econometric method to estimate causal effects when treatment or exposure is not randomly assigned and confounding is severe or unmeasured. IV relies on a third variable (instrument) that influences treatment but does not directly affect the outcome, allowing researchers to isolate the causal effect from the noise of confounding. Developed extensively in econometrics (Angrist & Pischke, 1990s–2000s), IV methods are increasingly used in health economics and health services research to leverage natural experiments and policy changes.	A Markov model is a decision-analytic tool that simulates disease progression through defined health states over time, calculating cumulative costs and quality-adjusted life years (QALYs) to enable cost-effectiveness analysis. Developed by Beck and Pauker in 1983, Markov models are now the standard framework for projecting long-term outcomes of health interventions, especially chronic diseases where patients transition between clinical states (treatment response, disease progression, remission, death). Used by health technology assessment bodies and pharmaceutical companies to predict intervention value beyond trial duration.