Methoden vergelijken

	IBD-kartering	QTL-mapping
Vakgebied	Genetica	Genetica
Familie	Process / pipeline	Process / pipeline
Jaar van ontstaan	1987	1989
Grondlegger	Eric Lander & David Botstein	Eric Lander & David Botstein
Type	Genomic mapping method	Genetic linkage method
Oorspronkelijke bron	Lander, E. S., & Botstein, D. (1987). Homozygosity mapping of autosomal recessive disorders in consanguineous families. American Journal of Human Genetics, 36(3), 537–551.	Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199.
Aliassen	IBD mapping, Autozygosity mapping, Homozygosity mapping	QTL analysis, Linkage mapping, Trait locus mapping
Verwant	4	4
Samenvatting	Identity-by-descent (IBD) mapping is a genetic mapping technique that identifies disease loci in consanguineous families or isolated populations by detecting homozygous chromosomal segments shared among affected individuals. Developed by Lander and Botstein in 1987, this method exploits the fact that rare disease alleles in related individuals must lie within shared ancestral DNA blocks. By mapping regions where affected individuals are homozygous at multiple markers, researchers can localize disease genes to narrowly defined genomic intervals without prior knowledge of the disease mechanism.	Quantitative trait loci (QTL) mapping is a genetic method that localizes chromosomal regions influencing quantitative traits—continuous phenotypes controlled by multiple genes and environmental factors. Developed by Lander and Botstein in 1989, QTL mapping uses linkage analysis and trait variation in segregating populations (such as F2 crosses or recombinant inbred lines) to identify genomic intervals containing loci that substantially affect trait values. This foundational approach has been extended to genome-wide association and is essential for understanding the genetic architecture of complex traits.