Methoden vergelijken

	F-statistieken (FST)	Analyse van LD-blokken	Selection Sweep (Tajima's D)
Vakgebied	Genetica	Genetica	Genetica
Familie	Process / pipeline	Process / pipeline	Process / pipeline
Jaar van ontstaan	1951	2002	1989
Grondlegger	Sewall Wright	Shaun Gabriel & Eric Lander	Fumio Tajima
Type	Population differentiation measure	Haplotype analysis method	Neutrality test
Oorspronkelijke bron	Wright, S. (1951). The genetical structure of populations. Annals of Eugenics, 15(4), 323–354.	Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., & Lander, E. S. (2002). The structure of haplotype blocks in the human genome. Science, 296(5576), 2225–2229.	Tajima, F. (1989). Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics, 123(3), 585–595.
Aliassen	FST, Wright's F-statistics, Population differentiation index	Haplotype block analysis, LD mapping, Block structure analysis	Tajima's D test, Selective sweep analysis, Neutrality test
Verwant	4	5	4
Samenvatting	F-statistics are a family of measures developed by Sewall Wright to quantify population genetic structure and the degree of genetic differentiation between populations. FST, the most widely used F-statistic, measures the proportion of total genetic variation attributable to differences between populations versus within populations. FST ranges from zero (no differentiation) to one (complete differentiation). These statistics have become fundamental tools for understanding population structure, detecting population admixture, and analyzing the evolutionary forces shaping genetic variation.	Linkage disequilibrium (LD) block analysis is a genomic method that partitions the human genome into distinct haplotype blocks—regions of limited recombination where variants are in strong statistical association. First systematically described by Gabriel and colleagues in 2002, this approach reveals the underlying structure of genetic variation and enables efficient genomic studies by reducing the number of variants needed to capture common diversity. LD block analysis forms the foundation of genome-wide association study (GWAS) design and modern population genetics.	Tajima's D is a statistical test designed to detect selective sweeps—recent, rapid fixation of advantageous mutations—from patterns of genetic variation in DNA sequences. Developed by Fumio Tajima in 1989, this test measures deviations from neutrality by comparing different measures of DNA sequence diversity. A significant Tajima's D value indicates departure from neutral evolution, suggesting positive selection, population structure, or demographic events.