Methoden vergelijken

	DEXA	PET Kinetische Modellering
Vakgebied	Medische beeldvorming	Medische beeldvorming
Familie	Process / pipeline	Process / pipeline
Jaar van ontstaan	1987	1983
Grondlegger	Harold Wahner	Christoph Patlak
Type	X-ray-based bone density measurement	Mathematical framework for tracer kinetics in PET imaging
Oorspronkelijke bron	Kanis, J. A. (1994). Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organization Technical Report Series, 843, 1-129.	Patlak, C. S., Blasberg, R. G., Fenstermacher, J. D. (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Journal of Cerebral Blood Flow & Metabolism, 3(1), 1-7.
Aliassen	Dual X-ray absorptiometry, DXA, bone densitometry	PET pharmacokinetics, Dynamic PET, PET compartmental modeling
Verwant	5	5
Samenvatting	Dual-Energy X-ray Absorptiometry (DEXA or DXA) is a non-invasive imaging technique that quantifies bone mineral density (BMD) by measuring the attenuation of X-rays at two different energies as they pass through bone and soft tissue. First developed by Wahner and colleagues in 1987, DEXA has become the gold standard for osteoporosis screening and fracture risk assessment. It is recommended by the World Health Organization for diagnosing osteoporosis and monitoring treatment response.	PET kinetic modeling is a quantitative analysis technique that tracks the temporal behavior of radioactive tracers in tissue to extract physiological parameters such as blood flow, metabolic rate, and receptor density. Established by Patlak, Logan, and Gunn in the 1980s and 1990s, kinetic modeling transforms raw PET time-activity curves into interpretable biological measures. It is widely used in neurology, oncology, and cardiology to assess disease severity, treatment response, and regional tissue function.