Methoden vergelijken
Bekijk de geselecteerde methoden naast elkaar; rijen die verschillen zijn gemarkeerd.
| Caco-2 Celpermeabiliteitsanalyse× | In Vitro-In Vivo Correlatie× | |
|---|---|---|
| Vakgebied | Farmacologie | Farmacologie |
| Familie | Process / pipeline | Process / pipeline |
| Jaar van ontstaan≠ | 1989 | 1995 |
| Grondlegger≠ | Ingrid Hidalgo | Gordon Amidon |
| Type≠ | absorption screening | bioavailability prediction |
| Oorspronkelijke bron≠ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ | Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12(3), 413-420. DOI ↗ |
| Aliassen≠ | Caco-2 assay, intestinal permeability, ADME screening | IVIVC |
| Verwant | 3 | 3 |
| Samenvatting≠ | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. | IVIVC is a mathematical relationship between in vitro and in vivo properties of a drug, developed to predict oral bioavailability from dissolution data. Introduced by Amidon and colleagues in the 1995 Biopharmaceutics Classification System, it bridges laboratory measurements and clinical outcomes to streamline drug development. |
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