Methoden vergelijken
Bekijk de geselecteerde methoden naast elkaar; rijen die verschillen zijn gemarkeerd.
| Caco-2 Celpermeabiliteitsanalyse× | Oplossing f1/f2-gelijkheidsfactor× | |
|---|---|---|
| Vakgebied | Farmacologie | Farmacologie |
| Familie | Process / pipeline | Process / pipeline |
| Jaar van ontstaan≠ | 1989 | 1996 |
| Grondlegger≠ | Ingrid Hidalgo | James Moore and Hector Flanner |
| Type≠ | absorption screening | similarity testing |
| Oorspronkelijke bron≠ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ | Moore, J. W., & Flanner, H. H. (1996). Mathematical comparison of dissolution profiles. Pharmaceutical Technology, 20(6), 64-74. link ↗ |
| Aliassen | Caco-2 assay, intestinal permeability, ADME screening | f1, f2, similarity factor |
| Verwant | 3 | 3 |
| Samenvatting≠ | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. | The f1 and f2 factors are dimensionless statistical measures developed by Moore and Flanner to quantify the similarity between two dissolution profiles. Adopted by regulatory agencies (FDA, EMA) as the gold standard for comparing dissolution curves, these factors enable rapid assessment of whether formulation changes significantly impact drug release. |
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