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| Kajian Ketepatan Diagnostik Prospektif× | Ujian Klinikal Rawak (RCT)× | |
|---|---|---|
| Bidang | Epidemiologi | Epidemiologi |
| Keluarga | Process / pipeline | Process / pipeline |
| Tahun asal≠ | Formalized 2000s; practice dates to mid-20th century | 1948 (first rigorously conducted RCT — MRC streptomycin trial) |
| Pengasas≠ | Established through STARD initiative (Bossuyt, Reitsma et al., 2000s) | Austin Bradford Hill; MRC Streptomycin Trial team |
| Jenis≠ | Observational / evaluative study design | Interventional experimental study |
| Sumber perintis≠ | Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L., ... & Cohen, J. F. (2015). STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ, 351, h5527. DOI ↗ | Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2015). Fundamentals of Clinical Trials (5th ed.). Springer. ISBN: 978-3319185385 |
| Alias | prospective DTA study, prospective test accuracy study, forward-looking diagnostic study, prospective index test evaluation | RCT, randomized controlled trial, randomised controlled trial, clinical randomized trial |
| Berkaitan | 6 | 6 |
| Ringkasan≠ | A prospective diagnostic accuracy study enrolls participants before any test results are known and follows them forward in time to evaluate how well an index test (the test under evaluation) distinguishes individuals with and without a target condition, using a reference standard applied independently. Key accuracy metrics include sensitivity, specificity, positive and negative predictive values, and the area under the ROC curve. The prospective design reduces many biases inherent in retrospective test evaluations. | A randomized clinical trial (RCT) is an experimental study design in which participants are randomly assigned to an intervention group or a control group, then followed prospectively to compare outcomes. Random allocation is the defining feature: it distributes known and unknown confounders across groups by chance, making the RCT the strongest individual study design for establishing causal efficacy of a treatment or intervention under controlled conditions. |
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