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Analisis Kepelbagaian Mikrobiom Bayesian×Analisis Filogenetik Bayesian×
BidangBioinformatikBioinformatik
KeluargaProcess / pipelineProcess / pipeline
Tahun asal2010s (Dirichlet-Multinomial approach formalized ~2012; extensions ongoing)1996–2001
PengasasIan Holmes, Katie Harris, Christopher Quince (Dirichlet-Multinomial Mixture framework, 2012); broader Bayesian microbiome modeling communityRannala & Yang (1996); operationalized by Huelsenbeck et al. (MrBayes, 2001)
JenisProbabilistic/Bayesian pipeline for compositional count dataProbabilistic inference method
Sumber perintisHolmes, I., Harris, K., & Quince, C. (2012). Dirichlet Multinomial Mixtures: Generative Models for Microbial Metagenomics. PLOS ONE, 7(2), e30126. link ↗Ronquist, F., & Huelsenbeck, J. P. (2003). MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics, 19(12), 1572–1574. DOI ↗
AliasBayesian microbiome profiling, Dirichlet-Multinomial microbiome analysis, Bayesian alpha/beta diversity, probabilistic microbiome diversityBayesian phylogenetics, Bayesian inference of phylogeny, MCMC phylogenetics, Bayesian molecular phylogenetics
Berkaitan53
RingkasanBayesian microbiome diversity analysis applies probabilistic models — chiefly Dirichlet-Multinomial and related hierarchical frameworks — to 16S rRNA or shotgun metagenomic count data to estimate alpha-diversity (within-sample richness and evenness) and beta-diversity (between-sample compositional differences) while propagating uncertainty through the entire inference chain. Unlike frequentist rarefaction-based approaches, Bayesian methods treat taxon counts as draws from a latent composition, enabling credible intervals on diversity metrics and principled comparison across groups with unequal sequencing depth.Bayesian phylogenetic analysis uses Bayes' theorem and Markov chain Monte Carlo (MCMC) sampling to estimate the posterior probability distribution over phylogenetic trees and model parameters given observed sequence data. Unlike bootstrapped maximum-likelihood methods that return a single best tree, Bayesian inference yields a credible set of trees with associated posterior probabilities, providing a principled measure of phylogenetic uncertainty. It is the dominant framework for estimating divergence times and ancestral relationships in molecular evolution.
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ScholarGateBandingkan kaedah: Bayesian Microbiome Diversity Analysis · Bayesian Phylogenetic Analysis. Dicapai 2026-06-17 daripada https://scholargate.app/ms/compare