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Pemantauan Obat Terapeutik (TDM)×Inferensi Bayesian×
BidangFarmakometrikaStatistika
KeluargaRegression modelBayesian methods
Tahun asal19881763
PencetusReynold Spector et al.Thomas Bayes; Pierre-Simon Laplace
TipeClinical measurement and dose-optimization frameworkProbabilistic inference paradigm
Sumber perintisSpector, R., Park, G. D., Johnson, G. F., & Vesell, E. S. (1988). Therapeutic drug monitoring. Clinical Pharmacology & Therapeutics, 43(4), 345–353. DOI ↗Bayes, T. (1763). An essay towards solving a problem in the doctrine of chances. Philosophical Transactions of the Royal Society of London, 53, 370–418. link ↗
AliasDrug Level Monitoring, Serum Drug Level Monitoring, Clinical Pharmacokinetic Monitoring, İlaç Düzeyi İzlemiBayes inference, Bayesian statistics, Bayesian updating, posterior inference
Terkait33
RingkasanTherapeutic Drug Monitoring (TDM) is a clinical pharmacokinetic practice in which drug concentrations are measured in a patient's blood to guide individualized dosing. It applies principally to drugs with narrow therapeutic windows—where the margin between efficacy and toxicity is small—such as aminoglycosides, vancomycin, cyclosporine, and antiepileptics. Developed as a formal discipline in the 1980s, TDM integrates measured concentrations with pharmacokinetic modeling to calculate patient-specific dose regimens.Bayesian inference is a statistical paradigm in which probability represents degrees of belief rather than long-run frequencies. It encodes prior knowledge about parameters in a prior distribution, combines that prior with the likelihood of observed data via Bayes' theorem, and produces a posterior distribution that quantifies updated uncertainty. The foundational theorem was published posthumously by Thomas Bayes in 1763 and subsequently systematized by Pierre-Simon Laplace in his 1812 Théorie analytique des probabilités.
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ScholarGateBandingkan metode: Therapeutic Drug Monitoring · Bayesian Inference. Diakses 2026-06-20 dari https://scholargate.app/id/compare