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| COSY× | Gema Putaran NMR× | |
|---|---|---|
| Bidang | Spektroskopi | Spektroskopi |
| Keluarga | Process / pipeline | Process / pipeline |
| Tahun asal≠ | 1976 | 1950 |
| Pencetus≠ | Wüthrich Kurt | Erwin Hahn |
| Tipe≠ | Two-dimensional pulse sequence | Spectroscopic pulse sequence |
| Sumber perintis≠ | Aue, W. P., Bartholdi, E., & Ernst, R. R. (1976). Two-dimensional spectroscopy. Application to nuclear magnetic resonance. The Journal of Chemical Physics, 64(5), 2229-2246. DOI ↗ | Hahn, E. L. (1950). Spin echoes. Physical Review, 80(4), 580-594. DOI ↗ |
| Alias≠ | COSY NMR, 2D COSY, 1H-1H COSY | CPMG pulse sequence, spin-echo NMR |
| Terkait | 4 | 4 |
| Ringkasan≠ | Correlation Spectroscopy (COSY) is a two-dimensional NMR technique that correlates proton chemical shifts through scalar coupling (J-coupling), revealing which protons are magnetically coupled and hence bonded through multiple bonds. Developed by Aue, Bartholdi, and Ernst in 1976, COSY became one of the most important tools in structural elucidation, enabling chemists to map out proton connectivity patterns and deduce molecular topology without isotopic labeling. | The spin-echo is a fundamental nuclear magnetic resonance (NMR) pulse sequence technique introduced by Erwin Hahn in 1950. It uses a 90-degree radiofrequency pulse followed by a 180-degree refocusing pulse to create an echo, effectively reversing the effects of magnetic field inhomogeneities and allowing accurate measurement of spin relaxation properties. This technique is essential in modern NMR spectroscopy for both one-dimensional and multidimensional experiments. |
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