Swelling and Degradation
The swelling and degradation assay measures how biomaterial scaffolds absorb water (swelling) and lose mass over time due to degradation. Developed by Wichterle and Lim in 1960 for hydrogels, the assay is fundamental for characterizing hydrogels, synthetic polymers, and composite scaffolds intended for tissue engineering. The assay provides quantitative data on swelling kinetics (equilibrium water content, swelling ratio), degradation kinetics (mass loss rate, half-life), and mechanisms of degradation (chain scission, enzymatic breakdown).
Izvorni zapis
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- Wichterle, O., & Lim, D. (1960). Hydrophilic gels for biological use. Nature, 185(4706), 117-118. · DOI 10.1038/185117a0
- Amsden, B. G., Sukarto, A., & Kilicalp, A. (2002). Assessment of an interpenetrating network of gelatin and poly (ethylene oxide) for cell encapsulation. Biomacromolecules, 3(3), 597-603. · URL
- Peppas, N. A., & Narasimhan, B. (1998). Mathematical models of protein release from degrading biopolymers. Journal of Controlled Release, 53(1-3), 233-243. · URL
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