विधियों की तुलना करें
चुनी हुई विधियों की आमने-सामने समीक्षा करें; भिन्नता वाली पंक्तियाँ रेखांकित हैं।
| फार्माकोविजिलेंस पीआरआर/आरओआर× | कैको-2 कोशिका पारगम्यता परख (Caco-2 Cell Permeability Assay)× | |
|---|---|---|
| क्षेत्र | औषध विज्ञान | औषध विज्ञान |
| परिवार | Process / pipeline | Process / pipeline |
| उद्भव वर्ष≠ | 2002 | 1989 |
| प्रवर्तक≠ | Arne Melander and colleagues | Ingrid Hidalgo |
| प्रकार≠ | safety signal detection | absorption screening |
| मौलिक स्रोत≠ | Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631. link ↗ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ |
| उपनाम≠ | PRR, ROR, signal detection, adverse event monitoring | Caco-2 assay, intestinal permeability, ADME screening |
| संबंधित | 3 | 3 |
| सारांश≠ | Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation. | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. |
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