השוואת שיטות

	ניסוי פקטוריאלי מלא עם סמיות יחידה	ניסוי מבוקר אקראי חד-סמיות
תחום	תכנון ניסויים	תכנון ניסויים
משפחה	Process / pipeline	Process / pipeline
שנת המקור	Full factorial: 1935 (Fisher); single-blind clinical convention: mid-20th century	1948 (formalized); single-blind variant established in mid-20th century clinical trial methodology
הוגה השיטה	Full factorial framework: R. A. Fisher; single-blind masking practice: clinical trial tradition, standardized by the 20th century	Bradford Hill and colleagues (MRC streptomycin trial, 1948); blinding conventions codified in CONSORT guidelines
סוג	Controlled experimental design	Experimental design — blinded randomized trial
מקור מכונן	Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. ISBN: 978-1119113478	Schulz, K. F., Altman, D. G., Moher, D., & CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332.
כינויים	single-masked full factorial, single-blind complete factorial, SB-FFE, single-blind all-combinations design	single-masked RCT, single-blind RCT, single-blind trial, SB-RCT
קשורות	6	5
תקציר	A single-blind full factorial experiment systematically tests every combination of all factor levels while keeping participants unaware of their treatment assignment. This design allows simultaneous estimation of all main effects and all interaction effects between factors, with single-blind masking reducing participant-side biases such as demand characteristics and expectation effects — without requiring investigator blinding.	A single-blind randomized controlled trial (SB-RCT) is a rigorous experimental design in which participants are randomly assigned to treatment or control conditions while remaining unaware of which condition they have received. Investigators, outcome assessors, and data analysts are not blinded. By masking participants, the design eliminates placebo and nocebo response biases on the participant side, while preserving investigator flexibility to administer and monitor the intervention.