השוואת שיטות

	ניתוח גרף סקאצ'רד	ניתוח שילד
תחום	פרמקולוגיה	פרמקולוגיה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1949	1947
הוגה השיטה	George Scatchard	Henry Schild
סוג	binding affinity measurement	antagonism quantification
מקור מכונן	Scatchard, G. (1949). The attractions of proteins for small molecules and ions. Annals of the New York Academy of Sciences, 51(4), 660-672.	Schild, H. O. (1947). pA, a new scale for the measurement of drug antagonism. Journal of Physiology, 106(3), 337-357.
כינויים	Scatchard plot, binding analysis, Kd determination	Schild plot, pA2
קשורות	3	3
תקציר	Scatchard analysis is a graphical method for determining ligand-receptor binding affinity (Kd) and binding capacity (Bmax) from binding data. Developed by George Scatchard in 1949, the Scatchard plot linearizes hyperbolic binding curves, enabling visual detection of multiple binding sites and quantitative parameter estimation.	Schild analysis is a quantitative method for characterizing competitive receptor antagonism developed by Henry Schild in 1947. It uses dose-response curves in the presence and absence of antagonist to estimate the antagonist affinity constant (pA2), enabling standardized comparison of antagonist potency across drugs and experimental systems.