השוואת שיטות

	ניתוח סמנים ביולוגיים ברוק	מדד DMFT (Decayed, Missing due to caries, Filled)
תחום	רפואת שיניים	רפואת שיניים
משפחה	Process / pipeline	Process / pipeline
שנת המקור	2000s+ (clinical application)	1938
הוגה השיטה	Multiple innovators (Giannobile, Malamud, et al.)	Henry Klein, Cedric Palmer, and James Knutson
סוג	Laboratory and point-of-care diagnostics	Epidemiological index
מקור מכונן	Giannobile, W. V., McDevitt, J. T., Niedbala, R. S., Malamud, D., & Prozorovsky, T. (2009). Translating molecular diagnostics into clinical practice: Designing the next generation of oral health technologies. Advances in Dental Research, 23(1), 80-89.	Klein, H., Palmer, C. E., & Knutson, J. W. (1938). Studies on dental caries: I. Dental status and dental needs of elementary school children. Public Health Reports, 53(32), 1259-1274.
כינויים	saliva testing, salivary diagnostics, oral biomarker assessment	DMF index, DMF score, DMFT score
קשורות	3	4
תקציר	Salivary biomarker analysis detects protein, molecular, or microbial markers in saliva that indicate oral and systemic disease. Salivary diagnostics assess risk and activity of dental caries, periodontal disease, oral cancer, and other conditions. Biomarkers include antimicrobial proteins (lysozyme, lactoferrin), inflammatory mediators (interleukins, TNF-alpha), cariogenic bacteria (Streptococcus mutans), and virulence factors. Point-of-care saliva testing offers rapid, non-invasive alternatives to conventional laboratory methods, enabling chairside diagnosis and personalized risk assessment.	The DMFT (Decayed, Missing due to caries, Filled) Index is a standardized epidemiological measure of dental caries experience in permanent dentition. Developed by Klein, Palmer, and Knutson in 1938, it quantifies the number of permanent teeth that are decayed, missing due to caries, or filled due to caries. The DMFT Index remains the most widely used caries index globally, enabling comparison of oral health across populations and tracking disease burden over time.