השוואת שיטות

	סקירת מטריה מבוססת פרוטוקול	ניתוח מטא-אנליזה רשתי
תחום	סיינטומטריה	סינתזת ראיות
משפחה	Process / pipeline	Process / pipeline
שנת המקור	2011-2015 (PROSPERO launched 2011; JBI umbrella review guidelines 2015)	2002
הוגה השיטה	Developed from umbrella review methodology; protocol registration practice formalized through PROSPERO (York) and JBI	Lumley (2002)
סוג	Registered evidence synthesis review	Method
מקור מכונן	Aromataris, E., Fernandez, R., Godfrey, C. M., Holly, C., Khalil, H., & Tungpunkom, P. (2015). Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review. JBI Evidence Implementation, 13(3), 132-140.	Lumley, T. (2002). Network meta-analysis for indirect treatment comparisons. Statistics in Medicine, 21(16), 2313–2324.
כינויים	pre-registered umbrella review, prospero-registered umbrella review, registered overview of reviews, protocol-driven umbrella review	Mixed Treatment Comparison, MTC, Indirect Comparison Meta-Analysis
קשורות	5	1
תקציר	A protocol-based umbrella review is an umbrella review — a synthesis of existing systematic reviews and meta-analyses on a common topic — conducted under a publicly pre-registered protocol, typically in PROSPERO or a similar registry. Pre-registering the protocol before data collection begins commits the research team to prospectively defined eligibility criteria, search strategy, appraisal tools, and synthesis methods, sharply reducing the risk of outcome reporting bias and post-hoc analytical flexibility.	Network meta-analysis (NMA) is a systematic method for comparing multiple interventions simultaneously within a single analytical framework, incorporating both direct evidence (head-to-head trials) and indirect evidence (comparisons via common comparators). First formalized by Lumley in 2002, NMA allows researchers to rank treatments and quantify comparative effectiveness even when some treatment pairs have never been directly studied.