השוואת שיטות

	מחקר אקולוגי פרגמטי	ניתוח מינון-תגובה
תחום	אפידמיולוגיה	אפידמיולוגיה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1967–1982 (pragmatic concept 1967; ecological study formalized ~1982)	Conceptual roots 16th century; modern epidemiological application mid-20th century
הוגה השיטה	Morgenstern (ecological study framework); Schwartz & Lellouch (pragmatic design concept)	Paracelsus (conceptual foundation); formalized by John Snow and later Bradford Hill
סוג	Observational ecological study with pragmatic framing	Quantitative analytical method
מקור מכונן	Morgenstern, H. (1982). Uses of ecologic analysis in epidemiologic research. American Journal of Public Health, 72(12), 1336–1344.	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
כינויים	real-world ecological study, effectiveness ecological study, population-level pragmatic study, pragmatic ecologic design	exposure-response analysis, concentration-response modeling, dose-response modeling, DRA
קשורות	5	4
תקציר	A pragmatic ecological study is an observational epidemiological design that examines associations between exposures and outcomes at the population or group level — using routinely collected, real-world data — with the explicit goal of informing practical public health decisions under everyday conditions. Rather than controlling every variable in a laboratory-like manner, it embraces the complexity and heterogeneity of natural settings to answer effectiveness questions relevant to policy.	Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.