השוואת שיטות

	אלקטרופיזיולוגיה בשיטת Patch-Clamp	מידול פרמקודנמי של אוכלוסיות
תחום	פרמקולוגיה	פרמקולוגיה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1976	1992
הוגה השיטה	Erwin Neher and Bert Sakmann	Lewis Sheiner and Stephen Roush
סוג	ion channel screening	dose-response modeling
מקור מכונן	Neher, E., & Sakmann, B. (1976). Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature, 260(5554), 799-802.	Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57.
כינויים	patch clamp, whole-cell recording, ion channel assay	PopPD, population PD, hierarchical PD modeling
קשורות	3	3
תקציר	Patch-clamp electrophysiology is a technique for measuring ionic currents through ion channels in cell membranes, developed by Neher and Sakmann in 1976. It enables direct observation of single-channel and whole-cell currents at millisecond resolution, making it essential for characterizing drug effects on ion channels and cardiac safety assessment.	Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction.