השוואת שיטות

	מחקר אקולוגי רב-מרכזי	ניתוח מינון-תגובה
תחום	אפידמיולוגיה	אפידמיולוגיה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1980s–1990s (formal methodological description)	Conceptual roots 16th century; modern epidemiological application mid-20th century
הוגה השיטה	Epidemiological tradition; methodologically articulated by Morgenstern (1982) and Susser (1994)	Paracelsus (conceptual foundation); formalized by John Snow and later Bradford Hill
סוג	Observational epidemiological study design	Quantitative analytical method
מקור מכונן	Morgenstern, H. (1982). Uses of ecologic analysis in epidemiologic research. American Journal of Public Health, 72(12), 1336–1344.	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
כינויים	multi-site ecological study, multinational ecological study, pooled ecological analysis, multicenter aggregate study	exposure-response analysis, concentration-response modeling, dose-response modeling, DRA
קשורות	6	4
תקציר	A multicenter ecological study is an observational epidemiological design in which the units of analysis are groups — such as cities, regions, or countries — rather than individuals, and data are pooled from two or more distinct centers or geographic areas. The approach links aggregate exposure measures (e.g., average pollution levels, vaccination coverage rates) to aggregate outcome rates (e.g., disease incidence per 100,000) across multiple populations, enabling comparisons that would be infeasible within any single site.	Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.