השוואת שיטות

	דיווח מקרה רב-מרכזי	סדרת מקרים
תחום	אפידמיולוגיה	אפידמיולוגיה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	Long-standing practice; CARE guidelines formalized 2013	Longstanding; systematized in 20th century clinical research
הוגה השיטה	Clinical medicine tradition; CARE guidelines by Gagnier et al.	Historical clinical practice; formalized in modern evidence-based medicine literature
סוג	Observational descriptive study	Observational descriptive study
מקור מכונן	Gagnier, J. J., Kienle, G., Altman, D. G., Moher, D., Sox, H., & Riley, D. (2013). The CARE guidelines: Consensus-based clinical case reporting guideline development. Journal of Medical Case Reports, 7, 223.	Case series. Wikipedia.
כינויים	multi-site case report, collaborative case report, multicentre case report, CARE multicenter report	case series report, clinical case series, consecutive case series, patient series
קשורות	4	5
תקציר	A multicenter case report is a structured clinical document describing one or a very small number of unusual patients observed across two or more independent healthcare institutions. By pooling observations from multiple sites, it overcomes the rarity barrier that prevents any single center from documenting an unusual presentation, adverse event, or novel treatment response — producing a richer, more externally valid account than a single-center report can offer.	A case series is a descriptive observational study that documents the characteristics, clinical course, and outcomes of a group of patients who share a common condition, exposure, or intervention. Unlike case reports, which focus on a single patient, a case series aggregates data across multiple patients (typically three or more) to identify patterns, generate hypotheses, and characterize rare or novel conditions — without a concurrent control group.