השוואת שיטות
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| ניתוח מטבולומי רב-אומי (Multi-omics Metabolomics Analysis)× | ניתוח מטבולומיקה× | |
|---|---|---|
| תחום | ביואינפורמטיקה | ביואינפורמטיקה |
| משפחה | Process / pipeline | Process / pipeline |
| שנת המקור≠ | 2000s–2010s (metabolomics ~2000; multi-omics integration ~2010s) | 1998–2002 |
| הוגה השיטה≠ | Pioneered collectively; key early integrative frameworks by Nicholson & Lindon (metabolomics) and Hasin, Seldin & Lusis (multi-omics disease mapping) | Oliver et al. (coining of 'metabolomics'); Oliver Fiehn (systematic framework) |
| סוג≠ | Integrative computational pipeline | Quantitative omics pipeline |
| מקור מכונן≠ | Subramanian, I., Verma, S., Kumar, S., Jere, A., & Anamika, K. (2020). Multi-omics data integration, interpretation, and its application. Bioinformatics and Biology Insights, 14, 1177932219899051. link ↗ | Fiehn, O. (2002). Metabolomics — the link between genotypes and phenotypes. Plant Molecular Biology, 48(1-2), 155–171. link ↗ |
| כינויים | metabolomics multi-omics integration, integrated metabolomics, multi-omics metabolite profiling, metabolome-centric multi-omics | metabolome profiling, metabolic profiling, metabonomics, metabolite profiling |
| קשורות≠ | 5 | 6 |
| תקציר≠ | Multi-omics metabolomics analysis integrates metabolite profiling data — derived from mass spectrometry or NMR spectroscopy — with genomic, transcriptomic, and/or proteomic datasets to build a system-level view of biological phenotypes. By anchoring integration on the metabolome, which reflects the downstream functional output of gene expression and protein activity, this approach connects upstream molecular variation to observable biochemical states, enabling richer mechanistic insight than any single omics layer alone. | Metabolomics analysis is the large-scale, systematic measurement of small-molecule metabolites in a biological sample to characterise the metabolome — the complete set of metabolic intermediates and products present under defined conditions. By coupling high-throughput analytical platforms such as mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectroscopy with multivariate statistics and pathway databases, metabolomics bridges the genotype–phenotype gap and captures the downstream functional output of genes, transcripts, and proteins in real time. |
| ScholarGateמערך נתונים ↗ |
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