השוואת שיטות

	תכנון ניסויי תערובת	תכנון מרכזי מורכב – תכנון ניסויי של משטח תגובה
תחום	תכנון ניסויים	תכנון ניסויים
משפחה	Hypothesis test	Process / pipeline
שנת המקור	1958	1951
הוגה השיטה	Henry Scheffé	George E. P. Box and K. B. Wilson
סוג	Constrained mixture experiment	Response surface experimental design
מקור מכונן	Scheffé, H. (1958). Experiments with Mixtures. Journal of the Royal Statistical Society, Series B, 20(2), 344–360.	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
כינויים	mixture experiment, simplex-lattice design, simplex-centroid design, Scheffé mixture design	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
קשורות	4	3
תקציר	Mixture experiment design is a class of constrained experimental design in which the factors are the proportions of components in a blend, subject to the constraint that all proportions sum to one. The framework was formalised by Henry Scheffé in 1958 and covers simplex-lattice, simplex-centroid, and D-optimal mixture designs widely used in pharmaceutical formulation, food science, and materials research.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.