השוואת שיטות

	תכנון מקרה-צילוב מותאם	תכנון מקרה-צולב
תחום	אפידמיולוגיה	אפידמיולוגיה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1991 (base design); matched variant refined ~1998–2000	1991
הוגה השיטה	Malcolm Maclure (case-crossover); time-matched variant developed by Navidi (1998) and Lumley & Levy (2000)	Malcolm Maclure
סוג	Observational epidemiological design	Observational epidemiological study design
מקור מכונן	Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.	Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.
כינויים	matched case-crossover study, time-matched case-crossover, bidirectional case-crossover, symmetric bidirectional design	case-crossover study, CCO design, self-matched case study, within-person crossover case study
קשורות	3	3
תקציר	The matched case-crossover design is a self-controlled observational study in which each case serves as its own control. A short hazard window immediately before the acute event is compared with one or more matched control windows — selected to have the same day of week, season, or other time-varying covariate — making the design robust to stable individual confounders and calendar-time trends simultaneously.	The case-crossover design is an observational epidemiological method that estimates whether a transient exposure triggers an acute event by comparing each case's exposure during a brief hazard window immediately before the event to their own exposure during earlier control periods. Because each person serves as their own control, all stable personal characteristics are automatically adjusted for, making the design especially powerful for studying intermittent exposures and sudden-onset outcomes such as myocardial infarction, stroke, or injury.