השוואת שיטות

	ציטומטריית מס דמוית-תמונה	מיפוי רגישות כמותי
תחום	הדמיה רפואית	הדמיה רפואית
משפחה	Process / pipeline	Process / pipeline
שנת המקור	2014	2015
הוגה השיטה	Bernd Bodenmiller	Yong Wang
סוג	Multiplexed single-cell imaging by mass spectrometry	Quantitative MRI contrast mechanism
מקור מכונן	Giesen, C., Wang, H. A., Schapiro, D., et al. (2014). Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry. Nature Methods, 11(4), 417-422.	Wang, Y., Liu, T. (2015). Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker. Magnetic Resonance in Medicine, 73(1), 82-101.
כינויים	IMC, mass cytometry, multiplex ion beam imaging, MIBI	QSM, susceptibility-weighted imaging
קשורות	5	5
תקציר	Imaging Mass Cytometry (IMC) is a multiplexed proteomics technique that maps the subcellular localization of up to 40-50 proteins in tissue sections simultaneously using mass spectrometry detection. Developed by Bodenmiller and colleagues in 2014, IMC combines the single-cell imaging power of immunofluorescence with the multiplexing capacity of mass cytometry, enabling comprehensive analysis of cell types, states, and spatial interactions within tissue microenvironments. IMC has emerged as a powerful tool in immuno-oncology, immunobiology, and tissue biology for dissecting cellular heterogeneity and spatial organization.	Quantitative Susceptibility Mapping (QSM) is a post-processing technique that converts MRI phase data into quantitative susceptibility values, enabling direct visualization and measurement of tissue magnetic properties. Developed by Wang, Liu, and colleagues, QSM transforms phase shifts caused by differences in magnetic susceptibility between tissues into tissue-specific biomarkers. It has revolutionized the sensitivity of MRI to iron, calcium, and other paramagnetic and diamagnetic substances, making it valuable in neurodegenerative disease diagnosis and tissue characterization.