השוואת שיטות

	אולטרסאונד פונקציונלי	מידול קינטי של PET
תחום	הדמיה רפואית	הדמיה רפואית
משפחה	Process / pipeline	Process / pipeline
שנת המקור	2011	1983
הוגה השיטה	Mickael Tanter	Christoph Patlak
סוג	High-framerate doppler imaging for hemodynamics	Mathematical framework for tracer kinetics in PET imaging
מקור מכונן	Macé, E., Montaldo, G., Trenholm, S., et al. (2011). Functional ultrasound imaging of the brain. Nature Methods, 8(8), 662-664.	Patlak, C. S., Blasberg, R. G., Fenstermacher, J. D. (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Journal of Cerebral Blood Flow & Metabolism, 3(1), 1-7.
כינויים	fUS, doppler ultrasound, ultrafast ultrasound	PET pharmacokinetics, Dynamic PET, PET compartmental modeling
קשורות	5	5
תקציר	Functional Ultrasound (fUS) is a high-framerate Doppler ultrasound technique that dynamically maps blood flow and hemodynamic changes in vivo with millisecond temporal resolution. Pioneered by Tanter, Macé, and colleagues in the 2010s, fUS enables real-time imaging of microvascular perfusion in the brain and other organs. By combining ultrafast acquisition (1000-5000 frames per second) with Doppler processing, fUS reveals functional activity (hemodynamic changes during stimulation or behavior) and vascular networks with unprecedented spatiotemporal detail.	PET kinetic modeling is a quantitative analysis technique that tracks the temporal behavior of radioactive tracers in tissue to extract physiological parameters such as blood flow, metabolic rate, and receptor density. Established by Patlak, Logan, and Gunn in the 1980s and 1990s, kinetic modeling transforms raw PET time-activity curves into interpretable biological measures. It is widely used in neurology, oncology, and cardiology to assess disease severity, treatment response, and regional tissue function.