השוואת שיטות

	קולומטריה	ניתוח בהזרקת זרימה	כרומטוגרפיית יונים	טיטרציה פוטנציומטרית
תחום	כימיה אנליטית	כימיה אנליטית	כימיה אנליטית	כימיה אנליטית
משפחה	Process / pipeline	Process / pipeline	Process / pipeline	Process / pipeline
שנת המקור	1945	1975	1975	1909
הוגה השיטה	James Lingane	Jaromir Ruzicka	Hamish Small	Soren Sorensen
סוג	electrochemical titration	continuous flow technique	separation and analysis technique	titration method
מקור מכונן	Lingane, J. J. (1974). Electroanalytical Chemistry (2nd ed.). Interscience Publishers. ISBN: 978-0486409023	Ruzicka, J., & Hansen, E. H. (1979). Flow injection analysis: Part 1. A new concept of fast continuous flow analysis. Analytica Chimica Acta, 106, 207–224.	Small, H., Stevens, T. S., & Bauman, W. C. (1989). Novel ion exchange chromatographic method using conductometric detection. Analytical Chemistry, 47(11), 1801–1809.	Skoog, D. A., West, D. M., Holler, F. J., & Crouch, S. R. (2014). Fundamentals of Analytical Chemistry (9th ed.). Cengage Learning. ISBN: 978-1133170960
כינויים	coulometric titration, electrochemical coulometry, amperes titration	FIA, sequential injection analysis, SIA, flow-based analysis	IC, ion-exchange chromatography, IEC	potentiometry, electrochemical titration
קשורות	5	5	5	5
תקציר	Coulometry is an electrochemical analytical method that determines the concentration of an analyte by measuring the total electric charge (in coulombs) required to oxidize or reduce the analyte completely at an electrode. Developed by James J. Lingane in the 1940s, coulometry is highly accurate because it is based on fundamental constants (Faraday's law) and does not require external standards or calibration curves. This method is particularly valuable for trace analysis, water determination, and analysis of reactive species.	Flow injection analysis is an automated continuous-flow technique that rapidly injects a sample plug into a flowing stream of carrier solution, where it mixes with reagents and is detected online before reaching the detector. Developed by Jaromir Ruzicka and Elo Hansen in 1975, FIA revolutionized analytical chemistry by enabling rapid, high-throughput analysis with minimal reagent consumption and waste. Flow injection analysis is widely used in pharmaceutical, food, environmental, and clinical laboratories for routine quantitative analysis.	Ion chromatography is a liquid chromatography method that separates ions and polar molecules based on their relative affinity for the ion exchange resin in the column. Developed by Hamish Small in 1975, it combines ion-exchange separation with conductivity detection, enabling rapid, sensitive, and simultaneous determination of multiple ions in a single analysis. Ion chromatography has become an indispensable tool for monitoring environmental pollutants, analyzing food and pharmaceutical products, and studying complex ionic mixtures.	Potentiometric titration is an electrochemical method of analysis that measures the potential difference between a reference electrode and an indicator electrode as a titrant is gradually added to a solution. Developed in the early 20th century, it allows precise determination of the concentration of analytes without requiring visual endpoint indicators. This method is fundamental in analytical chemistry for determining acids, bases, redox species, and metal ions.