השוואת שיטות

	כרומטוגרפיית עמוד	תכנון מסלול סינתזה	כרומטוגרפיית שכבה דקה
תחום	כימיה	כימיה	כימיה
משפחה	Process / pipeline	Process / pipeline	Process / pipeline
שנת המקור	1903	1969	1956
הוגה השיטה	Mikhail Tsvet	Elias James Corey	Egon Stahl
סוג	Chromatographic separation technique	Strategic planning methodology	Chromatographic separation technique
מקור מכונן	Skoog, D. A., Holler, F. J., & Crouch, S. R. (2017). Principles of Instrumental Analysis (7th ed.). Cengage Learning. ISBN: 978-1305577213	Corey, E. J., & Cheng, X. M. (1991). The Logic of Chemical Synthesis. John Wiley & Sons. ISBN: 978-0471096092	Sherma, J. (2003). Planar Chromatography. Analytical Chemistry, 75(12), 2783–2811.
כינויים	liquid chromatography, column liquid chromatography	retrosynthesis, retrosynthetic analysis, synthetic route design	TLC, planar chromatography
קשורות	3	3	3
תקציר	Column chromatography is a liquid separation technique in which a stationary phase (typically silica gel or alumina) is packed into a vertical column, and a mobile phase (solvent) percolates through it to separate mixture components. Pioneered by Mikhail Tsvet in 1903, column chromatography remains the workhorse of organic chemistry laboratories for purifying reaction products and isolating target compounds.	Synthesis route planning, grounded in retrosynthetic analysis, is a strategic approach to designing efficient chemical syntheses. Formalized by Elias James Corey in the 1960s (earning him the Nobel Prize in 1990), this methodology systematically deconstructs target molecules into simpler precursors and starting materials, enabling chemists to discover logical, economical, and practical synthesis routes.	Thin-Layer Chromatography (TLC) is a planar chromatographic technique that separates compounds based on their differential affinities for a mobile and stationary phase. Developed by Egon Stahl in 1956, TLC remains one of the most accessible and widely used analytical methods in organic and inorganic chemistry, laboratories, and quality control.