השוואת שיטות

	ניסוי אקראי מבוזר מרובה-זרועות	ניסוי מבוקר אקראי אדפטיבי
תחום	תכנון ניסויים	תכנון ניסויים
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1990s–2000s (systematic formalization)	1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947)
הוגה השיטה	Building on cluster randomization (Donner & Klar) and multi-arm trial methods developed in clinical and public health research	Donald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literature
סוג	Experimental design	Experimental design — adaptive variant of RCT
מקור מכונן	Donner, A., & Klar, N. (2000). Design and Analysis of Cluster Randomization Trials in Health Research. Arnold. ISBN: 978-0340691533	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690
כינויים	multi-arm cluster RCT, cluster-randomized multi-group trial, multi-arm group-randomized trial, CRCT multi-arm	Adaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trial
קשורות	6	6
תקציר	A cluster randomized multi-arm experiment assigns intact groups — such as schools, clinics, or villages — rather than individuals to three or more experimental conditions simultaneously. Randomization occurs at the cluster level to prevent contamination between arms, while the multi-arm structure allows simultaneous evaluation of several interventions against a common control or each other, improving efficiency over a series of two-arm studies.	An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.