השוואת שיטות

	בדיקות יציבות על פי ארניוס	PRR/ROR בפרמקולוגיה
תחום	פרמקולוגיה	פרמקולוגיה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1889	2002
הוגה השיטה	Svante Arrhenius	Arne Melander and colleagues
סוג	shelf-life prediction	safety signal detection
מקור מכונן	Arrhenius, S. (1889). Über die Reaktionsgeschwindigkeit bei der Inversion von Rohrzucker durch Säuren. Zeitschrift für Physikalische Chemie, 4, 226-248.	Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631.
כינויים	Arrhenius model, shelf-life prediction, degradation kinetics	PRR, ROR, signal detection, adverse event monitoring
קשורות	3	3
תקציר	Arrhenius stability testing predicts pharmaceutical product shelf-life by conducting accelerated degradation studies at elevated temperatures and using the Arrhenius equation to extrapolate to storage conditions. Based on Svante Arrhenius's 1889 equation relating reaction rate to temperature, this method is regulatory standard for establishing expiration dates.	Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation.