השוואת שיטות

	תכנון ניסוי פקטוריאלי מלא אדפטיבי	ניסוי מבוקר אקראי פקטוריאלי
תחום	תכנון ניסויים	תכנון ניסויים
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1950s (factorial foundations); adaptive extensions prominent from 1990s onward	1926 (Fisher factorial foundations); 2000s–2010s (clinical factorial RCT formalization)
הוגה השיטה	Rooted in Box & Hunter factorial design tradition; adaptive extensions formalised by Atkinson, Donev and others in optimal design theory	R. A. Fisher (factorial design foundations); adapted into clinical trials via MOST framework (Collins et al., 2014)
סוג	Experimental design	Experimental trial design
מקור מכונן	Atkinson, A., Donev, A., & Tobias, R. (2007). Optimum Experimental Designs, with SAS. Oxford University Press. ISBN: 978-0199296606	Collins, L. M., Dziak, J. J., Kugler, K. C., & Trail, J. B. (2014). Factorial experiments: Efficient tools for evaluation of intervention components. American Journal of Preventive Medicine, 47(4), 498–504.
כינויים	adaptive full-factorial design, sequential full factorial experiment, adaptive complete factorial design, dynamic full factorial trial	Factorial RCT, factorial trial, multi-factor RCT, factorial experiment with randomization
קשורות	5	6
תקציר	An adaptive full factorial experiment is an experimental design that starts with a complete crossing of all factors and all their levels, then uses interim data to modify subsequent runs — dropping unpromising factor levels, adding new ones, or re-allocating replication — while preserving the full factorial structure within each phase. This integration of full factorial coverage with adaptive decision rules allows researchers to explore all main effects and interactions without committing to a fixed, inefficient run plan before any data are observed.	A factorial randomized controlled trial (factorial RCT) is an experimental design in which participants are randomly assigned to every possible combination of two or more independent factors (treatments or intervention components) simultaneously. This allows researchers to estimate the main effect of each factor and their interactions within a single, efficient trial, rather than running separate experiments for each factor.