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| Yksittäisen solun ChIP-seq-piikkien tunnistus – scChIP-seq-epigenomiprofilointi× | ChIP-seq-piikkien tunnistus× | |
|---|---|---|
| Tieteenala | Bioinformatiikka | Bioinformatiikka |
| Menetelmäperhe | Process / pipeline | Process / pipeline |
| Syntyvuosi≠ | 2019 | 2007–2008 |
| Kehittäjä≠ | Grosselin et al.; Ku et al. (parallel independent development) | Johnson et al. (ChIP-seq concept, 2007); Zhang et al. (MACS algorithm, 2008) |
| Tyyppi≠ | Epigenomic profiling pipeline | Computational genomics pipeline |
| Alkuperäislähde≠ | Grosselin, K., Durand, A., Marsolier, J., Poitou, A., Marangoni, E., Nemati, F., ... & Vallot, C. (2019). High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer. Nature Genetics, 51(6), 1060-1066. link ↗ | Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., & Liu, X. S. (2008). Model-based analysis of ChIP-seq (MACS). Genome Biology, 9(9), R137. DOI ↗ |
| Rinnakkaisnimet | scChIP-seq peak calling, single-cell chromatin profiling, scChIC-seq analysis, single-cell epigenomic peak detection | ChIP-seq analysis, peak detection, MACS peak calling, ChIP peak identification |
| Liittyvät≠ | 5 | 6 |
| Tiivistelmä≠ | Single-cell ChIP-seq peak calling is a bioinformatics pipeline that identifies genomic regions enriched for histone modifications or transcription factor binding in individual cells. By profiling chromatin states at single-cell resolution, it reveals epigenomic heterogeneity hidden in bulk ChIP-seq experiments, enabling researchers to map regulatory landscapes across distinct cell populations within a complex tissue sample. | ChIP-seq peak calling is a computational pipeline that identifies genomic regions where a protein of interest — a transcription factor or histone modification — is enriched, based on sequencing reads from chromatin immunoprecipitation experiments. It converts raw sequencing data into a set of high-confidence binding or modification sites across the genome, enabling downstream analysis of gene regulation, chromatin state, and epigenetic mechanisms. |
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