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| Retrospektiivinen sisäkkäinen tapaus-verrokkitutkimus× | Sisäkkäinen tauti-verrokkitutkimus× | |
|---|---|---|
| Tieteenala | Epidemiologia | Epidemiologia |
| Menetelmäperhe | Process / pipeline | Process / pipeline |
| Syntyvuosi≠ | 1973 (formal description); widely adopted in epidemiology from 1980s onward | 1973–1977 |
| Kehittäjä≠ | Nested case-control formalized by Mantel (1973); retrospective application via historical cohort records | Nathan Mantel (1973); D. C. Thomas (1977 formalization) |
| Tyyppi≠ | Observational analytic study design | Hybrid observational study design |
| Alkuperäislähde≠ | Mantel, N. (1973). Synthetic retrospective studies and related topics. Biometrics, 29(3), 479–486. link ↗ | Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. link ↗ |
| Rinnakkaisnimet | retrospective NCC, nested case-control within retrospective cohort, case-control nested in historical cohort, nested CCR | NCC study, nested CC design, case-control within cohort, density sampling case-control |
| Liittyvät≠ | 5 | 6 |
| Tiivistelmä≠ | A retrospective nested case-control study is an efficient observational design in which cases and matched controls are sampled from within an already-assembled retrospective cohort. Exposure data are retrieved from historical records only for selected participants, dramatically reducing data-collection costs while retaining most of the analytic power of the full cohort. It is widely used in pharmacoepidemiology, occupational health, and disease-registry research. | A nested case-control study is an efficient observational design embedded within a defined cohort. For each participant who develops the outcome of interest (a case), a small number of matched controls are sampled from those still at risk at the same point in time. This density-sampling strategy yields odds ratios that approximate incidence-rate ratios from the full cohort at a fraction of the data-collection cost — making it the preferred alternative when measuring exposures for all cohort members would be prohibitively expensive or technically demanding. |
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