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| Sovitetun annos–vastetutkimuksen analyysi× | Paritettu tapausselä-kontrollitutkimus× | |
|---|---|---|
| Tieteenala | Epidemiologia | Epidemiologia |
| Menetelmäperhe | Process / pipeline | Process / pipeline |
| Syntyvuosi≠ | 1970s–1980s | 1950s–1970s |
| Kehittäjä≠ | Developed within the matched case-control framework; formalized by Breslow and Day (1980) and Rothman and colleagues | Brian MacMahon and others; systematised by Schlesselman (1982) |
| Tyyppi≠ | Analytical epidemiological method | Observational analytic design |
| Alkuperäislähde≠ | Rothman, K.J., Greenland, S., & Lash, T.L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641 | Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755474 |
| Rinnakkaisnimet | matched trend analysis, dose-response in matched designs, exposure-response analysis with matching, matched exposure-gradient analysis | matched case-referent study, individually matched case-control, pair-matched case-control, matched case-control design |
| Liittyvät≠ | 4 | 5 |
| Tiivistelmä≠ | Matched dose-response analysis evaluates whether increasing levels of exposure are associated with proportionally increasing (or decreasing) risk of an outcome, within a study where cases and controls — or exposed and unexposed individuals — have been deliberately matched on key confounders such as age, sex, or study site. Matching controls residual confounding structurally, while the dose-response component tests whether the exposure-outcome relationship follows a biologically plausible gradient, strengthening causal inference. | A matched case-control study is an observational epidemiological design in which each case (a person with the disease or outcome of interest) is paired with one or more controls (persons without the outcome) who share one or more characteristics — such as age, sex, or clinical setting — to control confounding. Exposure history is then compared between cases and their matched controls to estimate the odds ratio of the exposure-disease association. |
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