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| Differentiaalinen epigenomilaajuinen assosiaatiotutkimus× | ChIP-seq-piikkien tunnistus× | |
|---|---|---|
| Tieteenala | Bioinformatiikka | Bioinformatiikka |
| Menetelmäperhe | Process / pipeline | Process / pipeline |
| Syntyvuosi≠ | 2009–2011 | 2007–2008 |
| Kehittäjä≠ | Rakyan, Down, Balding & Beck (2011); Irizarry group for differential methylation methods (~2009–2014) | Johnson et al. (ChIP-seq concept, 2007); Zhang et al. (MACS algorithm, 2008) |
| Tyyppi≠ | Comparative epigenome-wide analysis | Computational genomics pipeline |
| Alkuperäislähde≠ | Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541. link ↗ | Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., & Liu, X. S. (2008). Model-based analysis of ChIP-seq (MACS). Genome Biology, 9(9), R137. DOI ↗ |
| Rinnakkaisnimet | Differential EWAS, comparative EWAS, epigenome-wide differential methylation analysis, EWAS differential design | ChIP-seq analysis, peak detection, MACS peak calling, ChIP peak identification |
| Liittyvät | 6 | 6 |
| Tiivistelmä≠ | A Differential Epigenome-Wide Association Study (Differential EWAS) scans hundreds of thousands of CpG methylation sites across the genome to identify those whose methylation levels differ significantly between two or more comparison groups — such as cases vs. controls, exposed vs. unexposed, or distinct developmental stages. It is the standard epigenomic analogue of a differential expression analysis but operates at the level of DNA methylation marks rather than RNA counts. | ChIP-seq peak calling is a computational pipeline that identifies genomic regions where a protein of interest — a transcription factor or histone modification — is enriched, based on sequencing reads from chromatin immunoprecipitation experiments. It converts raw sequencing data into a set of high-confidence binding or modification sites across the genome, enabling downstream analysis of gene regulation, chromatin state, and epigenetic mechanisms. |
| ScholarGateAineisto ↗ |
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