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| ALS Functional Rating Scale Revised (ALSFRS-R)× | Modified Rankin Scale (mRS)× | |
|---|---|---|
| Tieteenala | Neurologia | Neurologia |
| Menetelmäperhe | Process / pipeline | Process / pipeline |
| Syntyvuosi≠ | 1999 | 1988 |
| Kehittäjä≠ | James M. Cedarbaum, NIH/NINDS | Rankin scale original (Rankin, 1957); modified version by van Swieten et al. |
| Tyyppi≠ | Clinician-rated and patient-reported hybrid | Clinician-rated ordinal scale |
| Alkuperäislähde≠ | Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., & Nakanishi, A. (1999). The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function. Journal of the Neurological Sciences, 169(1-2), 13-21. DOI ↗ | van Swieten, J. C., Koudstaal, P. J., Visser, M. C., Schouten, H. J., & van Gijn, J. (1988). Interobserver agreement for the assessment of handicap in stroke patients. Stroke, 19(5), 604-607. DOI ↗ |
| Rinnakkaisnimet≠ | ALS FRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised | mRS, Rankin Scale, Modified Rankin |
| Liittyvät | 4 | 4 |
| Tiivistelmä≠ | The ALSFRS-R is a 12-item clinician-administered functional rating scale designed to assess disease progression and functional status in amyotrophic lateral sclerosis (ALS). Introduced by Cedarbaum and colleagues in 1999, it expands upon the original ALSFRS by incorporating respiratory function assessment. It is the primary outcome measure in ALS clinical trials and routine clinical monitoring, providing quantitative tracking of disease decline that predicts survival and guides management decisions. | The Modified Rankin Scale is a simple 0-6 ordinal measure of global disability or dependency in patients with stroke and other neurological conditions. Originally developed by Rankin in 1957 and modified by van Swieten and colleagues in 1988, it remains the most widely used global disability outcome in stroke clinical trials and clinical practice. Its simplicity, brevity, and strong prognostic association make it the gold standard for acute stroke outcome measurement and is mandated as a primary endpoint in virtually all stroke therapeutic trials. |
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