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Mukautuva kohorttitutkimus×Kohorttitutkimus×
TieteenalaEpidemiologiaEpidemiologia
MenetelmäperheProcess / pipelineProcess / pipeline
Syntyvuosi2000s–2010s (systematic formalisation)Mid-20th century (formal epidemiological design codified ~1950s)
KehittäjäExtension of classic cohort methods; adaptive design principles formalised by regulatory and epidemiology communities in the 2000s–2010sDoll & Hill (British Doctors Study, 1951); Snow (cholera, 1854)
TyyppiObservational / adaptive epidemiological designObservational longitudinal study design
AlkuperäislähdeVanderWeele, T. J., & Hernan, M. A. (2012). Results on differential and dependent measurement error of the exposure and the outcome using signed directed acyclic graphs. American Journal of Epidemiology, 175(12), 1303–1310. DOI ↗Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
Rinnakkaisnimetadaptive longitudinal study, flexible cohort design, adaptive prospective cohort, ACSlongitudinal study, follow-up study, panel study, incidence study
Liittyvät46
TiivistelmäAn adaptive cohort study is a longitudinal observational design that follows a defined group of individuals over time to assess exposure-outcome relationships, while incorporating pre-specified adaptation rules that allow protocol modifications — such as sample-size re-estimation, subgroup enrichment, or measurement schedule adjustments — based on accumulating interim data. Adaptations are made without compromising validity, guided by a statistical analysis plan agreed upon before data collection begins.A cohort study assembles a group of individuals who share a common starting point — typically freedom from the outcome of interest — and follows them over time to observe who develops the outcome. By comparing incidence rates between exposed and unexposed subgroups, researchers can estimate relative risk and absolute risk differences. Cohort studies are the gold-standard observational design for measuring disease incidence and establishing temporal relationships between exposure and outcome.
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ScholarGateVertaile menetelmiä: Adaptive Cohort Study · Cohort Study. Haettu 2026-06-17 osoitteesta https://scholargate.app/fi/compare