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طرح مورد-مقاطعه‌ای تعدیل‌شده بر اساس ریسک×مطالعه مورد-شاهدی×
حوزهاپیدمیولوژیاپیدمیولوژی
خانوادهProcess / pipelineProcess / pipeline
سال پیدایش1991 (base design); risk-adjustment extensions from mid-1990s onward1950s (formal methodology); precursors in the 1920s
پدیدآورMalcolm Maclure (case-crossover base); extensions incorporating covariate risk adjustment developed in subsequent pharmacoepidemiology literatureJanet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s
نوعObservational analytic epidemiological designObservational analytic study design
منبع بنیادینMaclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860
نام‌های دیگرadjusted case-crossover study, covariate-adjusted case-crossover, risk-controlled case-crossover, case-crossover with risk adjustmentcase-referent study, case-control design, retrospective case-control, case-control analysis
مرتبط46
خلاصهThe risk-adjusted case-crossover design is a self-matched epidemiological method that compares a person's exposure during a brief hazard window immediately preceding an acute event to their exposure during one or more control windows from the same individual, while formally accounting for time-varying or time-fixed covariates that could confound the exposure-event relationship. By using each case as their own control, stable individual-level confounders are automatically cancelled, while covariate adjustment handles residual time-varying risks.A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses.
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ScholarGateمقایسهٔ روش‌ها: Risk-adjusted case-crossover design · Case-control study. بازیابی‌شده در 2026-06-17 از https://scholargate.app/fa/compare