QTL Mapping
Quantitative trait loci (QTL) mapping is a genetic method that localizes chromosomal regions influencing quantitative traits—continuous phenotypes controlled by multiple genes and environmental factors. Developed by Lander and Botstein in 1989, QTL mapping uses linkage analysis and trait variation in segregating populations (such as F2 crosses or recombinant inbred lines) to identify genomic intervals containing loci that substantially affect trait values. This foundational approach has been extended to genome-wide association and is essential for understanding the genetic architecture of complex traits.
Allikakirje
Tsiteeringud kopeeritud meetodi allikakirjest sõna-sõnalt. Nendest ei saa järeldada väidete tasemel kinnitust.
- Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199. · URL
- Haley, C. S., & Knott, S. A. (1992). A simple regression method for mapping quantitative trait loci using molecular markers. Heredity, 69(4), 315–324. · DOI 10.1038/hdy.1992.131
- Kao, C. H., Zeng, Z. B., & Teasdale, R. D. (1999). Multiple interval mapping for quantitative trait loci. Genetics, 152(3), 1203–1216. · DOI 10.1093/genetics/152.3.1203
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