Individual Patient Data Meta-Analysis
Individual patient data meta-analysis (IPD-MA) is a systematic synthesis method where researchers obtain and analyze raw data at the patient level from multiple randomized controlled trials, rather than relying on published summary statistics (aggregate data). Pioneered by the Cochrane Collaboration and formalized by Stewart, Clarke, and Riley, IPD-MA is considered the gold standard for evidence synthesis because it enables consistent outcome definition across trials, robust subgroup analysis, and detection of treatment-covariate interactions. Though time-intensive and resource-demanding, IPD-MA provides the most reliable estimates of intervention effects and is preferred for critical clinical decisions, particularly for identifying which patients benefit most from treatment.
Registro de origen
Citas copiadas textualmente del registro de origen del método. No se infiere ninguna verificación a nivel de afirmación de ellas.
- Stewart, L. A., Clarke, M. J., & Cochrane IPD Meta-analysis Methods Group. (2015). Practical methodology of meta-analyses (including IPD) of randomised trials reporting time to event data. Cochrane Database of Systematic Reviews, 2015(10), MR000027. · URL
- Riley, R. D., Lambert, P. C., & Abo-Zaid, G. (2010). Meta-analysis of individual participant data: rationale, conduct, and reporting. BMJ, 340, c221. · DOI 10.1136/bmj.c221
- Higgins, P. T., & Green, S. (Eds.). (2011). Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). The Cochrane Collaboration. · URL
Afirmaciones curadas
Afirmaciones persistidas en el libro mayor de evidencia, cada una con su propia evaluación.
Esta vista no inventa una evaluación de afirmación si el libro mayor no tiene ninguna.
Métodos relacionados
Generado a partir del grafo de métodos y mostrado como relaciones sugeridas por la máquina; no se infiere ninguna afirmación de evidencia.