Comparar métodos

	Diseño Matched Case-Crossover	Estudio de Casos y Controles Emparejado
Campo	Epidemiología	Epidemiología
Familia	Process / pipeline	Process / pipeline
Año de origen	1991 (base design); matched variant refined ~1998–2000	1950s–1970s
Autor original	Malcolm Maclure (case-crossover); time-matched variant developed by Navidi (1998) and Lumley & Levy (2000)	Brian MacMahon and others; systematised by Schlesselman (1982)
Tipo	Observational epidemiological design	Observational analytic design
Fuente seminal	Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755474
Alias	matched case-crossover study, time-matched case-crossover, bidirectional case-crossover, symmetric bidirectional design	matched case-referent study, individually matched case-control, pair-matched case-control, matched case-control design
Relacionados	3	5
Resumen	The matched case-crossover design is a self-controlled observational study in which each case serves as its own control. A short hazard window immediately before the acute event is compared with one or more matched control windows — selected to have the same day of week, season, or other time-varying covariate — making the design robust to stable individual confounders and calendar-time trends simultaneously.	A matched case-control study is an observational epidemiological design in which each case (a person with the disease or outcome of interest) is paired with one or more controls (persons without the outcome) who share one or more characteristics — such as age, sex, or clinical setting — to control confounding. Exposure history is then compared between cases and their matched controls to estimate the odds ratio of the exposure-disease association.